The UK is a global leader in the delivery of national, evidence-based early intervention in psychosis. Our goal is to extend the breadth of this impact to common mental health disorders, such as depression, bipolar disorder and anxiety disorders. By intervening earlier in the life-course we are taking a truly preventative approach with focus on potential causes including bullying, deprivation, substance misuse and childhood trauma. It’s been a busy year for members of the Primed+ Lab at the IMH. The PRIMED+ (Psychosis Risk Immune Multimodal Early Detection Plus) research group is particularly interested in how environmental biological measures can help identify individuals who are at increased risk for developing psychosis, and early outcomes after psychosis has occurred. These are findings that can be translated into targeted interventions.